![]() On the other hand, all studied impurities were found to be hepatotoxic. ![]() The results showed that the three impurities under investigation had poor permeability to CNS and cannot pass the blood–brain barrier (BBB), reducing the likelihood of causing side effects in the brain. In-silico study was conducted for estimation of pharmacokinetic parameters (ADMET) as well as toxicity profile of the proposed impurities. The present study aims to quantify the combination of captopril (CPL), hydrochlorothiazide (HCZ) and their harmful impurities captopril disulphide (CDS), chlorothiaizde (CTZ) and salamide (SMD). It is a major cause of premature death worldwide. ![]() Hypertension is described by the world health organization (WHO) as a serious medical problem that significantly affects the heart, brain and kidneys. ![]()
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